When high therapeutic doses are used progress should be followed with frequent blood calcium determinations. IN VITAMIN D RESISTANT RICKETS THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW. Dosage levels must be individualized and great care exercised to prevent serious toxic effects. Therapeutic dosage should be readjusted as soon as there is clinical improvement. Vitamin D administration from fortified foods, dietary supplements, self-administered and prescription drug sources should be evaluated. Inactive Ingredients: Refined soybean oil, gelatin, glycerin, purified water, D&C Yellow #10, and FD&C Blue #1. One USP Unit of vitamin D2 is equivalent to one International Unit (IU), and 1 mcg of vitamin D2 is equal to 40 IU.Įach softgel, for oral administration, contains Ergocalciferol, USP 1.25 mg (equivalent to 50,000 USP units of Vitamin D), in an edible vegetable oil.Įrgocalciferol, also called vitamin D2, is 9,10-secoergosta-5,7,10(19),22-tetraen-3-ol,(3β,5Z,7E,22E)- (C28H44O) with a molecular weight of 396.65, and has the following structural formula: There are more than 10 substances belonging to a group of steroid compounds, classified as having vitamin D or antirachitic activity.
Ergosterol or provitamin D2 is found in plants and yeast and has no antirachitic activity.
ERGOCALCIFEROL CAPSULES, USP, is a synthetic calcium regulator for oral administration.Įrgocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils.
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